Protein Details: Voltage-gated potassium channel subunit beta-3

Protein ID

ICDB_Pro_1053

Protein Name

Voltage-gated potassium channel subunit beta-3

Gene Name

Kcnab3; Ckbeta3

Organism

Rattus norvegicus (Rat)

Length

404 amino acids

AlphaFoldDB

AF-Q63494-F1-model_v4.pdb

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.4 but not Kv1.1 or Kv1.5

Sequence

MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPVGGGHGNPPGGGGLGSKSRTAVVPRPPAPAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLQGSLDRLQLEYVDIVFANRSDPSSPMEEIVRAMTYVINQGLALYWGTSRWSAAEIMEAYSMARQFNLIPPVCEQAENHFFQREKVEMQLPELYHKIGVGSVTWSPLACSLITSKYDGQVPDACKATVKGYQWLKEKVQSEDGKKQQARVTDLLPIAHQLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLMEHLGSLQVLGQLTPQTVMEIDALLGNKSHSKK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

97;98;104;126;199;229;230;255;284;285;286;287;288;289;295;305;364;366;370;373

Disease

Location

Predominantly expressed in brain. Strongest expression in olfactory bulb and thalamic nuclei. Not detected in heart; spleen; lung; liver; skeletal muscle; kidney and testis.

DOI ID

10.1016/0014-5793(95)01377-6

RefSeq

NP_113840.1